("Cape Girardeau" redirects here. For the Cape Girardeau meteorite of 1846, see Meteorite fall. For ships named Cape Girardeau, see SS Cape Girardeau.) Cape Girardeau (/ˈkeɪp dʒᵻˈrɑːrdoʊ/, French: Cap-Girardeau [kap ʒiʁaʁdo] ; colloquially referred to as "Cape") is a city in Cape Girardeau and Scott counties in the U.S. state of Missouri. It is located approximately 115 miles (185 km) southeast of St. Louis and 175 miles (282 km) north of Memphis. As of the 2010 U.S. Census, the city's population was 37,941, making it the 16th-largest city in Missouri, and the largest city in Southeast Missouri. An emerging college town, it is the home of Southeast Missouri State University.

Explore popular vacation packages for Cape Girardeau, United States and kick-start your vacation planning for free. When planning a trip to Cape Girardeau, make sure you visit its near-by prime city of Saint Louis. So, ideally any vacation planner would recommend you to visit Saint Louis for its bountiful attractions like Gateway Arch, Saint Louis Zoo, City Museum on your trip to Cape Girardeau. Get in the character of the city, this city requires at least of 1 to 2 number of days of exploration.

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