As much as I love the train service in Italy, how Trenitalia manages their train stations is terrible and Mestre is one of the worst. They have done some extensive renovations. Does that mean the station is open during the night, so travelers have a waiting area for early morning trains inside? No. They finally put in elevators to reach the platforms, so do you no longer have to carry your luggage down and up the stairs? No, the elevators are generally out of service. They removed the old benches on the platforms, so did they put new ones there? No, they just removed them, now there is nothing to sit down on. Also, if you are not used to traveling by train in Italy, be advised that Mestre is one of those stations where trains almost never arrive on the platform they are supposed to. For whatever reason (or no reason at all) there will most likely be an announcement a few minutes before the train comes through, informing you that the train will arrive at another platform. Listen to the announcements and try to make out the origin/destination of your train during the Italian announcement, even if you don't speak Italian. In the English version the computer voice misspronounces some Italian place names in such a way that it's hard to make out what it is saying. If you feel lost or in need of assistance, tell someone (Trenitalia staff or fellow travelers), they'll surely help you out, if they can.

The train station is closed between 1 - 4:30am. If you have a morning train/bus, especially in the winter or cold season, I'd recommend you to change the timing. There is no waiting room, no cafes, no fast food places working at that time nearby. You will have to wait outside, even the hotel lobbies aren't open because of the security concers here.

We were a bit confused when we first entered but we found the ticket machines very easy to navigate. After a quick chat with the staff at the info stand we found out which platforms and what times departured for Venice. It was so straight forward and the trains were so efficient also. Would easily ferl comfortable navigating about it again by myself.

Central station full of tourists. Center of Mestre city. Is possible buy tickets to Venezia for 2,60€ per person. We went to Bergamo with Flixbus.

I had to take an early morning train out of this station. The station is closed until 4:30 am, so we sat outside for a bit waiting. While we were there, a fight broke out on the street and a Gang of four men jumped another man. They beat him with a pole and, despite people alleging that police presence was strong in this area, there was no one to be found the rest of our time there. Fearing for our safety, we tried to enter a hotel lobby across the street. We told the clerk about the fight, but he wouldn't even open the doors to listen to us. We simply mimed a fight and to call the police. He did nothing. This area is NOT SAFE, especially for female travelers. There are gangs walking around and several prostitutes around as well. If you can avoid it, I recommend it.